From Nashville International Airport:

• Take I-40W to Nashville.
• Follow I-40 west through town.
• Take exit # 207 (28th Avenue).
• When exiting the Interstate, bear to the right and go about .2 miles to the light, which should intersect with Jefferson Street.
• At the light, turn right on to Jefferson Street.
• Go about .6 miles down Jefferson Street to the next light; this will be 21st Avenue.
• Turn right at the light onto 21st Avenue, and go one block to Meharry Medical College.

From Memphis, Tennessee via I-40E:

• Take I-40E to Nashville.
• Exit the Interstate at exit # 207 (Jefferson Street); bear to the right onto Jefferson Street.
• Go about .3 miles down Jefferson Street to the first light; this will be 21st Avenue.
• Turn right at the light onto 21st Avenue, and go one block to Meharry Medical College.

From Bowling Green, Kentucky via I-65:

• Take I-65S to Nashville, then to I-40W.
• Take exit # 207 (28th Avenue); bear to the right and go about .2 miles, to the light, which should intersect with Jefferson Street.
• At the light, turn right onto Jefferson Street.
• Go about .6 miles down Jefferson Street to the next light; this will be 21st Avenue.
• Turn right at the light onto 21st Avenue, and go one block to Meharry Medical College.

From Knoxville, Tennessee via I-40W:

• Take I-40W to Nashville.
• Follow I-40 west through town.
• Take exit # 207 (28th Avenue).
• When exiting the Interstate, bear to the right and go about .2 miles to the light, which should intersect with Jefferson Street.
• At the light, turn right on to Jefferson Street.
• Go about .6 miles down Jefferson Street to the next light; this will be 21st Avenue.
• Turn right at the light onto 21st Avenue, and go one block to Meharry Medical College.

From Fort Campbell, Kentucky via I-24:

• Take I-24E to Nashville, then to I-65S.
• Get on I-65S to I-40W.
• Take I-40W to exit # 207 (28th Avenue).
• Take exit # 207 (28th Avenue).
• When exiting the Interstate, bear to the right and go about .2 miles, to the light, which should intersect with Jefferson Street.
• At the light, turn right on to Jefferson Street.
• Go about .6 miles down Jefferson Street to the next light; this will be 21st Avenue.
• Turn right at the light onto 21st Avenue, and go one block to Meharry Medical College.

From Chattanooga, Tennessee/Atlanta, Georgia On I-24W:

• Take I-24W to Nashville, then exit toward I-440W by-pass headed toward Memphis.
• Take I-440W by-pass to I-40E; exit on to I-40E.
• Take I-40E to exit # 207 (Jefferson Street).
• Exit the Interstate at exit # 207 (Jefferson Street); bear to the right onto Jefferson Street.
• Go about .3 miles down Jefferson Street to the first light; this will be 21st Avenue.
• Turn right at the light onto 21st Avenue, and go one block to Meharry Medical College.

From Birmingham, Alabama, via I-65N:

• Take I-65N to Nashville
• Exit on to I-440W by-pass, headed toward Memphis.
• Exit to I-40E.
• Take I-40E to Exit #207 (Jefferson Street.)
• Exit the Interstate at exit # 207 (Jefferson Street); bear to the right onto Jefferson Street.
• Go about .3 miles down Jefferson Street to the first light; this will be 21st Avenue.
• Turn right at the light onto 21st Avenue, and go one block to Meharry Medical College.