Clinical Research

Are you a researcher wishing to collaborate with Meharry on a scientific question? Are you a member of the general public interested in clinical trials, having lost a family member to breast cancer? ‘Clinical research’ requires both the concerned citizen and the scientific investigator working together. We also conduct ‘translational research’—translating research from the lab to drugs/treatments for the public at large.

 

To the general public, Meharry says consider registering as a research volunteer in the Participant and Clinical Interactions Resource office. You may also want to register at researchMatch.org, where you can learn about studies taking place at other institutions as well.

 

To researchers, particularly Meharry’s investigators, the College says welcome. Explore the PCIR and core facilities (as well as services available to you through the Grants Management Office and Office for Grants Development). Meharry’s Board of Trustees is committed to growing the services available to the College’s researchers. As this growth takes place, what Meharry lacks in size it more than makes up for in personal attention. Your contribution to the research community at Meharry is valued.

Core Facilites

The goal of our core facilities at Meharry Medical College is to provide state of the art technology, advanced expertise, and teaching of technologies to our faculty and their research staff and trainees. We offer a variety of facilities to support research from bench to bedside to community.

The BSL-3/FACS Core provides a safe and appropriate environment for the investigation of infectious agents such as HIV on the Meharry Medical College campus. The FACS Corexx provides a state-of-the-art multi-parameter flow cytometry and cell sorting facility. The facility performs sorting, provides expertise in implementing and developing technologies for cell analysis, and trains investigators in the use of the instrumentation and the interpretation of data analysis. For contact information and equipment details, click here.

The Human Tissue Acquisition and Pathology Core (human tumor acquisition, histology, and immunohistochemistry) establishes human tissue procurement at Meharry Medical College/Nashville General Hospital to enhance translational research efforts at Meharry and increase the collection of tissues form African Americans and other minority groups. Read more.

The Meharry Microarray and Bioinformatics Core (MMBC) provides state of the art training, instrumentation, services, and bioinformatics-driven data analysis to the Meharry community in microarray experimental design, manipulation, and gene expression analysis. MMBC also validates microarray results using RNA QA/QC and real time PCR results and provides high performance computation in proteomics as well as genomics, as well as gene and protein pathways analysis and shotgun proteomics (mass spectrometry) analysis. Read more.

The Endocrine Core is a fully accredited, CLIA approved, endocrine testing facility funded by the Meharry Medical College Clinical Research Center, U54 Reproductive Health Grants, and institutional resources. The Endocrine Core Lab performs a comprehensive list of routine and specialized endocrine tests on blood samples for government funded investigators. A full staff of board certified clinical endocrinologists and clinical scientists are available for consultation and interpretation of test results. Read more.

The Molecular Biology Core at Meharry Medical College is a multi-functional facility that provides to faculty, students, and staff the primary service of DNA sequencing but also provides access to shared equipment housed in a centralized location and facilitates convenient and rapid access to frequently used molecular biological reagents. Read more.

The Fluorescence Microscopy Morphology Core offers fluorescence and bright-field microscopy and immunohistochemistry to investigators at Meharry. Read more.

The Clinical & Translational Research Center (CTRC) is a joint effort of multiple agencies designed to cultivate researchers’ expertise as clinical investigators by providing the resources ordinarily not available to them for designing, building, and conducting clinical studies. CTRC has a full, specially skilled, nursing staff, and laboratory equipment. Read more.

The Meharry Proteomics Core aids investigators and trainees with high performance computation in proteomics, as well as other “omics” type applications needing efficient analysis of large-scale biological data sets. The ability to incorporate proteomics into translational and clinical biomedical research is critical for the discovery of therapeutic interventions and high fidelity biomarkers of disease and response to therapy. The Core provides state-of-the-art services, training, and bioinformatics-driven data analysis to the Meharry translational research community. Read more.

The Animal Care Facility (ACF) at Meharry Medical College has been accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International(AAALAC) since 1972 and operates in compliance with the Animal Welfare Act as Amended (7 USC, 2131-2156); Health Research Extension Act of 1985 (Public Law 99-158); follows the Public Health Service policy on Human Care and Use of Laboratory Animals (revised 2015); and the Guide for the Care and Use of Laboratory Animals revised 2010.

 

 

Meharry’s laboratory animal veterinarian and technical staff provide primary and veterinary care to all animals housed, as well as investigator training, technical assistance and guidance, and access to health status and  laboratory services. Our goal is the maintenance of an enriched, variable-free, secure, and humane environment for our animal subjects, as well as superb customer service for our research clients.

 

Notable Aspects and Capabilities of the Meharry Medical College include:

 

 

·        AAALACi Accredited

The Animal Care Facility (ACF) at Meharry Medical College is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International(AAALAC) since 1972.

 

·        USDA Registered Research Facility

Meharry is registered as a Research Facility with the US Department of Agriculture (Certificate 63-R-0002).

·        OLAW Animal Welfare Assurance

Meharry maintains a Letter of Assurance (A-3420-01) with the Public Health Service’s Office of Laboratory Animal Welfare

 

·        Environmental monitoring/alarm system monitored 24/7/365

 

The Vivarium’s environmental monitoring, control and alarm systems integrate and coordinate the use of set of temperature, humidity, air flow, amperage draw and related sensors to provide timely and comprehensive data regarding room and mechanical condition. Key environment components monitored include:

 

  • Room temperature
  • Power failure
  • Room humidity
  • Air handler operation
  • Cooling system capacity utilization
  • Outside temperature and humidity
  • Air flow rates in cubic feet per minute
  • Room pressurization
  • Status of room lighting
  • Status of key mechanical components (e.g., chillers, boilers, pumps)

These are all monitored both on- and off-campus by Meharry Facilities Management. System diagnoses and adjustments can be made from any Web-capable device.

 

Animal room temperatures may be set individually, as can key environmental alarm set points.

Administration

Brenda Y. Lemus, M.D.
Senior Associate Dean for Clinical Research
Director, Clinical and Translational Research Center (CTRC)
Assistant Professor, Professional and Medical Education
615.327.5611
blemus@mmc.edu